A prospective microbiome-wide association study of food sensitization and food allergy in early childhood.

ABSTRACT:

Background

Alterations in the intestinal microbiome are prospectively associated with the development of asthma; less is known regarding the role of microbiome alterations in food allergy development.

Methods

Intestinal microbiome samples were collected at age 3-6 months in children participating in the follow-up phase of an interventional trial of high-dose vitamin D given during pregnancy. At age 3, sensitization to foods (milk, egg, peanut, soy, wheat, walnut) was assessed. Food allergy was defined as caretaker report of healthcare provider-diagnosed allergy to the above foods prior to age 3 with evidence of IgE sensitization. Analysis was performed using Phyloseq and DESeq2; P-values were adjusted for multiple comparisons.

Results

Complete data were available for

SUBMITTER: Savage JH 

PROVIDER: S-EPMC5921051 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature