Application of the DSM-5 Criteria for Major Neurocognitive Disorder to Vascular MCI Patients.

ABSTRACT:

Aims

The DSM-5 introduced the term "major neurocognitive disorders" (NCDs) to replace the previous term "dementia." However, psychometric and functional definitions of NCDs are missing. We aimed to apply the DSM-5 criteria for diagnosing the transition to NCD to patients with mild cognitive impairment (MCI) and small vessel disease (SVD), and to define clinically significant thresholds for this transition.

Methods

The functional and cognitive features of the NCD criteria were evaluated as change from baseline and operationalized according to hierarchically ordered psychometric rules.

Results

According to the applied criteria, out of 138 patients, 44 were diagnosed with major NCD (21 with significant cognitive worsening in ≥1 additional cognitive domain), 84 remained s

SUBMITTER: Salvadori E 

PROVIDER: S-EPMC5921186 | biostudies-literature | 2018 Jan-Apr

REPOSITORIES: biostudies-literature