Adverse events profile of oral corticosteroids among asthma patients in the UK: cohort study with a nested case-control analysis.

ABSTRACT:

Background

To evaluate the adverse events profile of oral prednisolone among adult asthma patients in the UK.

Methods

Using data from the UK-based Clinical Practice Research Datalink, we conducted a series of cohort studies to quantify incidence rates and incidence rate ratios, and a series of nested case-control analyses to estimate crude and adjusted odds ratios, of 11 different potential corticosteroid-related adverse events (bone-related conditions, hypertension, peptic ulcer, severe infections, herpes zoster, diabetes mellitus type 2, cataract, glaucoma, chronic kidney disease, affective disorders, and cardiovascular events).

Results

Between 165,900 and 269,368 asthma patients were included in each of the 11 cohorts, of whom between 836 and 16,192 developed an ou

SUBMITTER: Bloechliger M 

PROVIDER: S-EPMC5921395 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature