Synthesis, antimicrobial evaluation and docking studies of some novel quinazolinone Schiff base derivatives.

ABSTRACT: The quinazolin-4(3H)-one structural motif possesses a wide spectrum of biological activities. DNA gyrase play an important role in induction of bacterial death. It has been shown that many quinazolin-4(3H)-one derivatives have antibacterial effects through inhibition of DNA gyrase. Based on this information we decided to synthesize novel quinazolinone Schiff base derivatives in order to evaluate their antibacterial effects. A series of novel quinazolinone Schiff base derivatives were designed and synthesized from benzoic acid. The potential DNA gyrase inhibitory activity of these compounds was investigated using in silico molecular docking simulation. All new synthesized derivatives were screened for their antimicrobial activities against three species of Gram-negative bacteria including E

SUBMITTER: Nasab RR 

PROVIDER: S-EPMC5921402 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature