The release of cardioprotective humoral factors after remote ischemic preconditioning in humans is age- and sex-dependent.

ABSTRACT:

Background

Preclinical and proof-of-concept studies suggest a cardioprotective effect of remote ischemic preconditioning (RIPC). However, two major clinical trials (ERICCA and RIPHeart) failed to show cardioprotection by RIPC. Aging and gender might be confounding factors of RIPC affecting the inter-organ signalling. Theoretically, confounding factors might prevent the protective potency of RIPC by interfering with cardiac signalling pathways, i.e. at the heart, and/or by affecting the release of humoral factor(s) from the remote organ, e.g. from the upper limb. This study investigated the effect of age and sex on the release of cardioprotective humoral factor(s) after RIPC in humans.

Methods

Blood samples were taken from young and aged, male and female volunteers before (co

SUBMITTER: Heinen A 

PROVIDER: S-EPMC5921545 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature