Identification of interneurons required for the aversive response of Caenorhabditis elegans to graphene oxide.

ABSTRACT:

Background

So far, how the animals evade the environmental nanomaterials is still largely unclear. In this study, we employed in vivo assay system of Caenorhabditis elegans to investigate the aversive behavior of nematodes to graphene oxide (GO) and the underlying neuronal basis.

Results

In this assay model, we detected the significant aversive behavior of nematodes to GO at concentrations more than 50 mg/L. Loss-of-function mutation of nlg-1 encoding a neuroligin with the function in connecting pre- and post-synaptic neurons suppressed the aversive behavior of nematodes to GO. Moreover, based on the neuron-specific activity assay, we found that the NLG-1 activity in AIY or AIB interneurons was required for the regulation of aversive behavior to GO. The neuron-specific activ

SUBMITTER: Xiao G 

PROVIDER: S-EPMC5921546 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature