Familial resemblances in human whole blood transcriptome.

ABSTRACT:

Background

Considering the implication of gene expression in the susceptibility of chronic diseases and the familial clustering of chronic diseases, the study of familial resemblances in gene expression levels is then highly relevant. Few studies have considered the contribution of both genetic and common environmental effects to familial resemblances in whole blood gene expression levels. The objective is to quantify the contribution of genetic and common environmental effects in the familial resemblances of whole blood genome-wide gene expression levels. We also make comparisons with familial resemblances in blood leukocytes genome-wide DNA methylation levels in the same cohort in order to further investigate biological mechanisms.

Results

Maximal heritability, genetic her

SUBMITTER: Tremblay BL 

PROVIDER: S-EPMC5921553 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature