Neutral models of short-term microbiome dynamics with host subpopulation structure and migration limitation.

ABSTRACT:

Background

Most empirical studies tend to focus on microbiome dynamics within hosts or microbiome compositional differences between hosts over short periods. However, there is still a dearth of formal models that allow us to investigate the observed short-term dynamics of microbiomes under a unified ecological and evolutionary framework. In our previous study, we developed a computational agent-based neutral framework that simulates microbiome dynamics spanning many host generations with the added dimension of a genealogy of hosts. Although this long-term framework revealed interesting microbial diversity patterns under a simple but plausible evolutionary process and provided a platform for future elaboration of more complex systems, it does not allow us to explore microbiome dynam

SUBMITTER: Zeng Q 

PROVIDER: S-EPMC5921780 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature