Association Between Midlife Vascular Risk Factors and Estimated Brain Amyloid Deposition.

ABSTRACT:

Importance

Midlife vascular risk factors have been associated with late-life dementia. Whether these risk factors directly contribute to brain amyloid deposition is less well understood.

Objective

To determine if midlife vascular risk factors are associated with late-life brain amyloid deposition, measured using florbetapir positron emission tomography (PET).

Design, setting, and participants

The Atherosclerosis Risk in Communities (ARIC)-PET Amyloid Imaging Study, a prospective cohort study among 346 participants without dementia in 3 US communities (Washington County, Maryland; Forsyth County, North Carolina; and Jackson, Mississippi) who have been evaluated for vascular risk factors and markers since 1987-1989 with florbetapir PET scans in 2011-2013. Positron emiss

SUBMITTER: Gottesman RF 

PROVIDER: S-EPMC5921896 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature