A systematic review on the genetics of male infertility in the era of next-generation sequencing.

ABSTRACT:

Objectives

To identify the role of next-generation sequencing (NGS) in male infertility, as advances in NGS technologies have contributed to the identification of novel genes responsible for a wide variety of human conditions and recently has been applied to male infertility, allowing new genetic factors to be discovered.

Materials and methods

PubMed was searched for combinations of the following terms: 'exome', 'genome', 'panel', 'sequencing', 'whole-exome sequencing', 'whole-genome sequencing', 'next-generation sequencing', 'azoospermia', 'oligospermia', 'asthenospermia', 'teratospermia', 'spermatogenesis', and 'male infertility', to identify studies in which NGS technologies were used to discover variants causing male infertility.

Results

Altogether, 23 studies wer

SUBMITTER: Robay A 

PROVIDER: S-EPMC5922186 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature