A peripheral blood transcriptomic signature predicts autoantibody development in infants at risk of type 1 diabetes.

ABSTRACT: Autoimmune-mediated destruction of pancreatic islet β cells results in type 1 diabetes (T1D). Serum islet autoantibodies usually develop in genetically susceptible individuals in early childhood before T1D onset, with multiple islet autoantibodies predicting diabetes development. However, most at-risk children remain islet-antibody negative, and no test currently identifies those likely to seroconvert. We sought a genomic signature predicting seroconversion risk by integrating longitudinal peripheral blood gene expression profiles collected in high-risk children included in the BABYDIET and DIPP cohorts, of whom 50 seroconverted. Subjects were followed for 10 years to determine time of seroconversion. Any cohort effect and the time of seroconversion were corrected to uncover genes differen

SUBMITTER: Mehdi AM 

PROVIDER: S-EPMC5922278 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature