Peripheral tissues reprogram CD8+ T cells for pathogenicity during graft-versus-host disease.

ABSTRACT: Graft-versus-host disease (GVHD) is a life-threatening complication of allogeneic stem cell transplantation induced by the influx of donor-derived effector T cells (TE) into peripheral tissues. Current treatment strategies rely on targeting systemic T cells; however, the precise location and nature of instructions that program TE to become pathogenic and trigger injury are unknown. We therefore used weighted gene coexpression network analysis to construct an unbiased spatial map of TE differentiation during the evolution of GVHD and identified wide variation in effector programs in mice and humans according to location. Idiosyncrasy of effector programming in affected organs did not result from variation in T cell receptor repertoire or the selection of optimally activated TE. Instead, TE

SUBMITTER: Santos E Sousa P 

PROVIDER: S-EPMC5922296 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature