Cross-sectional associations of plasma vitamin D with cerebral β-amyloid in older adults at risk of dementia.

ABSTRACT: BACKGROUND:Vitamin D deficiency is associated with an increased risk of Alzheimer's disease and increased beta-amyloid (Aβ) in animals. Hence we sought to investigate the relationship between plasma 25-hydroxyvitamin D (25(OH)D) and cerebral Aβ in older adults with subjective memory complaints. METHODS:This is a secondary analysis of the Multidomain Alzheimer Preventive Trial. Participants were 178 dementia-free individuals aged 70 years or older with data on plasma 25(OH)D and cerebral Aβ load assessed by [18F]-florbetapir positron emission tomography. Plasma 25(OH)D was measured at study baseline using a commercially available electro-chemiluminescence competitive binding assay. Standard uptake value ratios (SUVRs) were generated using the cerebellum as a reference. Brain regions assesse

SUBMITTER: Nourhashemi F 

PROVIDER: S-EPMC5922310 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature