Histone H4 acetylation regulates behavioral inter-individual variability in zebrafish.

ABSTRACT:

Background

Animals can show very different behaviors even in isogenic populations, but the underlying mechanisms to generate this variability remain elusive. We use the zebrafish (Danio rerio) as a model to test the influence of histone modifications on behavior.

Results

We find that laboratory and isogenic zebrafish larvae show consistent individual behaviors when swimming freely in identical wells or in reaction to stimuli. This behavioral inter-individual variability is reduced when we impair the histone deacetylation pathway. Individuals with high levels of histone H4 acetylation, and specifically H4K12, behave similarly to the average of the population, but those with low levels deviate from it. More precisely, we find a set of genomic regions whose histone H4 acetylati

SUBMITTER: Roman AC 

PROVIDER: S-EPMC5922312 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature