Isolated metastasis of an EGFR-L858R-mutated NSCLC of the meninges: the potential impact of CXCL12/CXCR4 axis in EGFR_mut NSCLC in diagnosis, follow-up and treatment.

ABSTRACT: Brain and leptomeningeal metastasis (LMM) of non-small cell lung cancer is still associated with poor prognosis. Moreover, the current diagnostic standard for LMM often yields false negative results and the scientific progress in this field is still unsatisfying. We present a case of a 71-year old patient with an isolated LMM. While standard diagnostics could only diagnose a cancer of unknown primary, the use of [⁶⁸Ga]-Pentixafor-PET/CT (CXCR4-PET/CT, a radiotracer targeting CXCR4) and a liquid biopsy of the cerebrospinal fluid revealed the primary NSCLC. The detection of L858R-EGFR, a common driver mutation in NSCLC, enabled us to treat the patient with Afatinib and monitor treatment using [⁶⁸Ga]-Pentixafor PET/CT. To estimate the impact of CXCR4 signaling and its li

SUBMITTER: Luke F 

PROVIDER: S-EPMC5922360 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature