Distinct molecular subtypes of gastric cancer: from Lauren to molecular pathology.

ABSTRACT: In Western countries the majority of gastric cancers (GC) are usually diagnosed in advanced stages reporting a 5-year survival rate of only 26%. The Laurén classification of GC was most widely used in clinical practice since it reflects GC morphology, epidemiology, tumor biology, clinical management and outcome. Despite the initial promise of individualizing antitumor treatment, the management of GC still remains relatively broad and general. Apart from clinical staging, molecular profiling enables targeting of the identified underlying alterations, rather than histology. In contrast to breast carcinoma, molecular classification of GC does not yet imply treatment modality. Molecular classifications of GC and their therapeutic implications are therefore extensively studied. The current prop

SUBMITTER: Cislo M 

PROVIDER: S-EPMC5922408 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature