Trajectories of cerebral cortical development in childhood and adolescence and adult attention-deficit/hyperactivity disorder.

ABSTRACT:

Background

Childhood attention-deficit/hyperactivity disorder (ADHD) persists into adulthood in around half of those affected, constituting a major public health challenge. No known demographic, clinical, or neuropsychological factors robustly explain the clinical course, directing our focus to the brain. Herein, we link the trajectories of cerebral cortical development during childhood and adolescence with the severity of adult ADHD.

Methods

Using a longitudinal study design, 92 participants with ADHD had childhood (mean 10.7 years, SD 3.3) and adult clinical assessments (mean 23.8 years, SD 4.3) with repeated neuroanatomic magnetic resonance imaging. Contrast was made against 184 matched typically developing volunteers.

Results

Attention-deficit/hyperactivity disord

SUBMITTER: Shaw P 

PROVIDER: S-EPMC5922431 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature