Hypertensive pregnancy complications in women with epilepsy and antiepileptic drugs: a population-based cohort study of first pregnancies in Norway.

ABSTRACT:

Objectives

To estimate the risk of hypertensive pregnancy complications in women with epilepsy, with and without antiepileptic drugs, and assess the risk associated with the four most common antiepileptic drugs.

Design

A population-based cohort study using linked data from the Medical Birth Registry of Norway and the Norwegian Prescription Database. Women with epilepsy with and without antiepileptic drugs were compared with women without epilepsy.

Setting

Norway, 2004-2012.

Participants

All first pregnancies of women with epilepsy and women without epilepsy were included.

Primary and secondary outcome measures

Main outcome measures were hypertensive pregnancy complications: a compound variable of any hypertensive disorder, gestational hypertension, mild

SUBMITTER: Danielsson KC 

PROVIDER: S-EPMC5922520 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature