Expression of the eight GABAA receptor α subunits in the developing zebrafish central nervous system.

ABSTRACT: GABA is a robust regulator of both developing and mature neural networks. It exerts many of its effects through GABAA receptors, which are heteropentamers assembled from a large array of subunits encoded by distinct genes. In mammals, there are 19 different GABAA subunit types, which are divided into the α, β, γ, δ, ε, π, θ and ρ subfamilies. The immense diversity of GABAA receptors is not fully understood. However, it is known that specific isoforms, with their distinct biophysical properties and expression profiles, tune responses to GABA. Although larval zebrafish are well-established as a model system for neural circuit analysis, little is known about GABAA receptors diversity and expression in this system. Here, using database analysis, we show that the zebrafish genome contains at le

SUBMITTER: Monesson-Olson B 

PROVIDER: S-EPMC5922542 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature