On the role of extrinsic noise in microRNA-mediated bimodal gene expression.

ABSTRACT: Several studies highlighted the relevance of extrinsic noise in shaping cell decision making and differentiation in molecular networks. Bimodal distributions of gene expression levels provide experimental evidence of phenotypic differentiation, where the modes of the distribution often correspond to different physiological states of the system. We theoretically address the presence of bimodal phenotypes in the context of microRNA (miRNA)-mediated regulation. MiRNAs are small noncoding RNA molecules that downregulate the expression of their target mRNAs. The nature of this interaction is titrative and induces a threshold effect: below a given target transcription rate almost no mRNAs are free and available for translation. We investigate the effect of extrinsic noise on the system by introd

SUBMITTER: Del Giudice M 

PROVIDER: S-EPMC5922620 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature