OMGene: mutual improvement of gene models through optimisation of evolutionary conservation.

ABSTRACT:

Background

The accurate determination of the genomic coordinates for a given gene - its gene model - is of vital importance to the utility of its annotation, and the accuracy of bioinformatic analyses derived from it. Currently-available methods of computational gene prediction, while on the whole successful, frequently disagree on the model for a given predicted gene, with some or all of the variant gene models often failing to match the biologically observed structure. Many prediction methods can be bolstered by using experimental data such as RNA-seq. However, these resources are not always available, and rarely give a comprehensive portrait of an organism's transcriptome due to temporal and tissue-specific expression profiles.

Results

Orthology between genes provides evo

SUBMITTER: Dunne MP 

PROVIDER: S-EPMC5923031 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature