Human T Lymphocytes Are Permissive for Dengue Virus Replication.

ABSTRACT: Dengue virus (DV) infection can cause either a self-limiting flu-like disease or a threatening hemorrhage that may evolve to shock and death. A variety of cell types, such as dendritic cells, monocytes, and B cells, can be infected by DV. However, despite the role of T lymphocytes in the control of DV replication, there remains a paucity of information on possible DV-T cell interactions during the disease course. In the present study, we have demonstrated that primary human naive CD4⁺ and CD8⁺ T cells are permissive for DV infection. Importantly, both T cell subtypes support viral replication and secrete viable virus particles. DV infection triggers the activation of both CD4⁺ and CD8⁺ T lymphocytes, but preactivation of T cells reduces the susce

SUBMITTER: Silveira GF 

PROVIDER: S-EPMC5923084 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature