Role of Microvesicles in the Spread of Herpes Simplex Virus 1 in Oligodendrocytic Cells.

ABSTRACT: Herpes simplex virus 1 (HSV-1) is a neurotropic pathogen that can infect many types of cells and establishes latent infections in the neurons of sensory ganglia. In some cases, the virus spreads into the central nervous system, causing encephalitis or meningitis. Cells infected with several different types of viruses may secrete microvesicles (MVs) containing viral proteins and RNAs. In some instances, extracellular microvesicles harboring infectious virus have been found. Here we describe the features of shedding microvesicles released by the human oligodendroglial HOG cell line infected with HSV-1 and their participation in the viral cycle. Using transmission electron microscopy, we detected for the first time microvesicles containing HSV-1 virions. Interestingly, the Chinese hamster ova

SUBMITTER: Bello-Morales R 

PROVIDER: S-EPMC5923088 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature