Heavy Metal Resistance Genes Are Associated with <i>bla</i>_NDM-1- and <i>bla</i>_CTX-M-15-Carrying Enterobacteriaceae.

ABSTRACT: The occurrence of heavy metal resistance genes in multiresistant Enterobacteriaceae possessing bla_NDM-1 or bla_CTX-M-15 genes was examined by PCR and pulsed-field gel electrophoresis with S1 nuclease. Compared with clinical susceptible isolates (10.0% to 30.0%), the pcoA, merA, silC, and arsA genes occurred with higher frequencies in bla_NDM-1-positive (48.8% to 71.8%) and bla_CTX-M-15-positive (19.4% to 52.8%) isolates, and they were mostly located on plasmids. Given the high association of metal resistance genes with multidrug-resistant Enterobacteriaceae, increased vigilance needs to be taken with the use of heavy metals in hospitals and the environment.

SUBMITTER: Yang QE 

PROVIDER: S-EPMC5923091 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature