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Heavy Metal Resistance Genes Are Associated with <i>bla</i><sub>NDM-1</sub>- and <i>bla</i><sub>CTX-M-15</sub>-Carrying Enterobacteriaceae.

ABSTRACT: The occurrence of heavy metal resistance genes in multiresistant Enterobacteriaceae possessing blaNDM-1 or blaCTX-M-15 genes was examined by PCR and pulsed-field gel electrophoresis with S1 nuclease. Compared with clinical susceptible isolates (10.0% to 30.0%), the pcoA, merA, silC, and arsA genes occurred with higher frequencies in blaNDM-1-positive (48.8% to 71.8%) and blaCTX-M-15-positive (19.4% to 52.8%) isolates, and they were mostly located on plasmids. Given the high association of metal resistance genes with multidrug-resistant Enterobacteriaceae, increased vigilance needs to be taken with the use of heavy metals in hospitals and the environment.

SUBMITTER: Yang QE 

PROVIDER: S-EPMC5923091 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Heavy Metal Resistance Genes Are Associated with &lt;i&gt;bla&lt;/i&gt;&lt;sub&gt;NDM-1&lt;/sub&gt;- and &lt;i&gt;bla&lt;/i&gt;&lt;sub&gt;CTX-M-15&lt;/sub&gt;-Carrying Enterobacteriaceae.

Yang Qiu E QE   Agouri Siham Rajab SR   Tyrrell Jonathan Mark JM   Walsh Timothy Rutland TR  

Antimicrobial agents and chemotherapy 20180426 5

The occurrence of heavy metal resistance genes in multiresistant <i>Enterobacteriaceae</i> possessing <i>bla</i><sub>NDM-1</sub> or <i>bla</i><sub>CTX-M-15</sub> genes was examined by PCR and pulsed-field gel electrophoresis with S1 nuclease. Compared with clinical susceptible isolates (10.0% to 30.0%), the <i>pcoA</i>, <i>merA</i>, <i>silC</i>, and <i>arsA</i> genes occurred with higher frequencies in <i>bla</i><sub>NDM-1</sub>-positive (48.8% to 71.8%) and <i>bla</i><sub>CTX-M-15</sub>-positiv  ...[more]

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