Acylhydrazones as Antifungal Agents Targeting the Synthesis of Fungal Sphingolipids.

ABSTRACT: The incidence of invasive fungal infections has risen dramatically in recent decades. Current antifungal drugs are either toxic, likely to interact with other drugs, have a narrow spectrum of activity, or induce fungal resistance. Hence, there is a great need for new antifungals, possibly with novel mechanisms of action. Previously our group reported an acylhydrazone called BHBM that targeted the sphingolipid pathway and showed strong antifungal activity against several fungi. In this study, we screened 19 derivatives of BHBM. Three out of 19 derivatives were highly active against Cryptococcus neoformansin vitro and had low toxicity in mammalian cells. In particular, one of them, called D13, had a high selectivity index and showed better activity in an animal model of cryptococcosis, candi

SUBMITTER: Lazzarini C 

PROVIDER: S-EPMC5923120 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature