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In Vitro Antifungal Activity of Novel Triazole Efinaconazole and Five Comparators against Dermatophyte Isolates.

ABSTRACT: The objective of this study was to assess the in vitro activity of the novel triazole antifungal drug, efinaconazole, and five comparators (luliconazole, lanoconazole, terbinafine, itraconazole, and fluconazole) against a large collection of Trichophyton interdigitale and Trichophyton rubrum clinical isolates. The geometric mean MICs were the lowest for luliconazole (0.0005 ?g/ml), followed by lanoconazole (0.002 ?g/ml), efinaconazole (0.007 ?g/ml), terbinafine (0.011 ?g/ml), itraconazole (0.095 ?g/ml), and fluconazole (12.77 ?g/ml). It appears that efinaconazole, lanoconazole, and luliconazole are promising candidates for the treatment of dermatophytosis due to T. interdigitale and T. rubrum.

SUBMITTER: Rezaei-Matehkolaei A

PROVIDER: S-EPMC5923135 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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In Vitro Antifungal Activity of Novel Triazole Efinaconazole and Five Comparators against Dermatophyte Isolates.

Rezaei-Matehkolaei Ali A Khodavaisy Sadegh S Alshahni Mohamad Mahdi MM Tamura Takashi T Satoh Kazuo K Abastabar Mahdi M Shokoohi Gholam Reza GR Ahmadi Bahram B Kord Mohammad M Taghipour Simin S Makimura Koichi K Badali Hamid H

Antimicrobial agents and chemotherapy 20180426 5

The objective of this study was to assess the in vitro activity of the novel triazole antifungal drug, efinaconazole, and five comparators (luliconazole, lanoconazole, terbinafine, itraconazole, and fluconazole) against a large collection of Trichophyton interdigitale and Trichophyton rubrum clinical isolates. The geometric mean MICs were the lowest for luliconazole (0.0005 μg/ml), followed by lanoconazole (0.002 μg/ml), efinaconazole (0.007 μg/ml), terbinafine (0.011 μg/ml) ...[more]

PMID: 29530856

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