Elevated MIC Values of Imidazole Drugs against Aspergillus fumigatus Isolates with TR₃₄/L98H/S297T/F495I Mutation.

ABSTRACT: The use of azole fungicides in agriculture is believed to be one of the main reasons for the emergence of azole resistance in Aspergillus fumigatus Though widely used in agriculture, imidazole fungicides have not been linked to resistance in A. fumigatus This study showed that elevated MIC values of imidazole drugs were observed against A. fumigatus isolates with TR₃₄/L98H/S297T/F495I mutation, but not among isolates with TR₃₄/L98H mutation. Short-tandem-repeat (STR) typing analysis of 580 A. fumigatus isolates from 20 countries suggested that the majority of TR₃₄/L98H/S297T/F495I strains from China were genetically different from the predominant major clade comprising most of the azole-resistant strains and the strains with the

SUBMITTER: Chen Y 

PROVIDER: S-EPMC5923150 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature