Prediction Model for Antimalarial Activities of Hemozoin Inhibitors by Using Physicochemical Properties.

ABSTRACT: The rapid spread of strains of malaria parasites that are resistant to several drugs has threatened global malaria control. Hence, the aim of this study was to predict the antimalarial activity of chemical compounds that possess anti-hemozoin-formation activity as a new means of antimalarial drug discovery. After the initial in vitro anti-hemozoin-formation high-throughput screening (HTS) of 9,600 compounds, a total of 224 hit compounds were identified as hemozoin inhibitors. These 224 compounds were tested for in vitro erythrocytic antimalarial activity at 10 μM by using chloroquine-mefloquine-sensitive Plasmodium falciparum strain 3D7A. Two independent experiments were conducted. The physicochemical properties of the active compounds were extracted from the ChemSpider and SciFinder datab

SUBMITTER: Mosaddeque F 

PROVIDER: S-EPMC5923155 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature