The rat pancreatic body tail as a source of a novel extracellular matrix scaffold for endocrine pancreas bioengineering.

ABSTRACT:

Background

Regenerative medicine and tissue engineering are promising approaches for organ transplantation. Extracellular matrix (ECM) based scaffolds obtained through the decellularization of natural organs have become the preferred platform for organ bioengineering. In the field of pancreas bioengineering, acellular scaffolds from different animals approximate the biochemical, spatial and vascular relationships of the native extracellular matrix and have been proven to be a good platform for recellularization and in vitro culture. However, artificial endocrine pancreases based on these whole pancreatic scaffolds have a critical flaw, specifically their difficult in vivo transplantation, and connecting their vessels to the recipient is a major limitation in the development of panc

SUBMITTER: Yu H 

PROVIDER: S-EPMC5923185 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature