Ontology highlight
ABSTRACT:
SUBMITTER: Taki M
PROVIDER: S-EPMC5923228 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Nature communications 20180427 1
Snail is a major transcriptional factor that induces epithelial-mesenchymal transition (EMT). In this study, we explore the effect of Snail on tumor immunity. Snail knockdown in mouse ovarian cancer cells suppresses tumor growth in immunocompetent mice, associated with an increase of CD8<sup>+</sup> tumor-infiltrating lymphocytes and a decrease of myeloid-derived suppressor cells (MDSCs). Snail knockdown reduces the expression of CXCR2 ligands (CXCL1 and CXCL2), chemokines that attract MDSCs to ...[more]