Long non-coding RNAs involved in the regulatory network during porcine pre-implantation embryonic development and iPSC induction.

ABSTRACT: Long non-coding RNAs (lncRNA) play a key role in the orchestration of transcriptional regulation during development and many other cellular processes. The importance of the regulatory co-expression network was highlighted in the identification of the mechanism of these processes in humans and mice. However, elucidation of the properties of porcine lncRNAs involved in the regulatory network during pre-implantation embryonic development and fibroblast reprogramming to induced pluripotent stem cell (iPSC) has been limited to date. Using a weighted gene co-expression network analysis, we constructed the regulatory network and determined that the novel lncRNAs were functionally involved in key events of embryonic development during the pre-implantation period; moreover, reprogramming could be d

SUBMITTER: Zhong L 

PROVIDER: S-EPMC5923264 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature