Multidrug-resistant Pseudomonas aeruginosa aggravates inflammatory responses in murine chronic colitis.

ABSTRACT: The World Health Organization has rated multidrug-resistant (MDR) Gram-negative bacteria including Pseudomonas aeruginosa (Psae) as serious threat to human health. We here addressed whether chronic murine gut inflammation facilitates intestinal MDR Psae colonization and whether bacterial infection subsequently worsens colonic immunopathology. Converse to wildtype counterparts, Psae colonized the intestines of IL-10^-/- mice with chronic colitis following peroral challenge, but did not lead to changes in intestinal microbiota composition. Psae infection accelerated both macroscopic (i.e. clinical) and microscopic disease (i.e. colonic epithelial apoptosis), that were accompanied by increased intestinal pro-inflammatory immune responses as indicated by elevated colonic numbers of i

SUBMITTER: von Klitzing E 

PROVIDER: S-EPMC5923287 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature