The Critical Role of Inflammation in the Pathogenesis and Progression of Myeloid Malignancies.

ABSTRACT: Hematopoietic stem cells (HSCs) maintain an organism's immune system for a lifetime, and derangements in HSC proliferation and differentiation result in hematologic malignancies. Chronic inflammation plays a contributory if not causal role in HSC dysfunction. Inflammation induces HSC exhaustion, which promotes the emergence of mutant clones that may be resistant to an inflammatory microenvironment; this likely promotes the onset of a myeloid hematologic malignancy. Inflammatory cytokines are characteristically high in patients with myeloid malignancies and are linked to disease initiation, symptom burden, disease progression, and worsened prognostic survival. This review will cover our current understanding of the role of inflammation in the initiation, progression, and complications of my

SUBMITTER: Craver BM 

PROVIDER: S-EPMC5923359 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature