Immunohistochemistry for Diagnosis of Metastatic Carcinomas of Unknown Primary Site.

ABSTRACT: Immunohistochemistry has become an essential ancillary examination for the identification and classification of carcinomas of unknown primary site (CUPs). Over the last decade, the diagnostic accuracy of organ- or tumour-specific immunomarkers and the clinical validation of effective immunohistochemical panels has improved significantly. When dealing with small sample sizes, diagnostic accuracy is crucial, particularly in the current era of targeted molecular and immune-based therapies. Effective systematic use of appropriate immunohistochemical panels enables accurate classification of most of the undifferentiated carcinomas as well as careful preservation of tissues for potential molecular or other ancillary tests. This review discusses the algorithmic approach to the diagnosis of CUPs u

SUBMITTER: Selves J 

PROVIDER: S-EPMC5923363 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature