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Further New Diterpenoids as PTP1B Inhibitors from the Xisha Soft Coral Sinularia polydactyla.

ABSTRACT: A new prenyleudesmane type diterpene, sinupol (8), and a new capnosane type diterpenoid, sinulacetate (9), were isolated from the Xisha soft coral Sinularia polydactyla along with five known related diterpenes (4-7 and 10). Their structures, including absolute configurations, were determined by extensive spectroscopic analysis, the comparison of their NMR data with those of related compounds, and time-dependent density functional theory electronic circular dichroism (TDDFT ECD) calculations. Both new compounds (8 and 9) exhibited promising inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), a potential drug target for the treatment of type II diabetes and obesity.

SUBMITTER: Ye F 

PROVIDER: S-EPMC5923390 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Further New Diterpenoids as PTP1B Inhibitors from the Xisha Soft Coral Sinularia polydactyla.

Ye Fei F   Zhu Zheng-Dan ZD   Gu Yu-Cheng YC   Li Jia J   Zhu Wei-Liang WL   Guo Yue-Wei YW  

Marine drugs 20180325 4

A new prenyleudesmane type diterpene, sinupol (<b>8</b>), and a new capnosane type diterpenoid, sinulacetate (<b>9</b>), were isolated from the Xisha soft coral <i>Sinularia polydactyla</i> along with five known related diterpenes (<b>4</b>-<b>7</b> and <b>10</b>). Their structures, including absolute configurations, were determined by extensive spectroscopic analysis, the comparison of their NMR data with those of related compounds, and time-dependent density functional theory electronic circul  ...[more]

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