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New Eudesmane-Type Sesquiterpenoids from the Mangrove-Derived Endophytic Fungus Penicillium sp. J-54.

ABSTRACT: Four new eudesmane-type sesquiterpenoids, penicieudesmol A-D (1-4), were isolated from the fermentation broth of the mangrove-derived endophytic fungus Penicillium sp. J-54. Their structures were determined by spectroscopic methods, the in situ dimolybdenum CD method, and modified Mosher's method. The bioassays results showed that 2 exhibited weak cytotoxicity against K-562 cells.

SUBMITTER: Qiu L 

PROVIDER: S-EPMC5923395 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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New Eudesmane-Type Sesquiterpenoids from the Mangrove-Derived Endophytic Fungus Penicillium sp. J-54.

Qiu Liuming L   Wang Pei P   Liao Ge G   Zeng Yanbo Y   Cai Caihong C   Kong Fandong F   Guo Zhikai Z   Proksch Peter P   Dai Haofu H   Mei Wenli W  

Marine drugs 20180328 4

Four new eudesmane-type sesquiterpenoids, penicieudesmol A-D (<b>1</b>-<b>4</b>), were isolated from the fermentation broth of the mangrove-derived endophytic fungus <i>Penicillium</i> sp. J-54. Their structures were determined by spectroscopic methods, the in situ dimolybdenum CD method, and modified Mosher's method. The bioassays results showed that <b>2</b> exhibited weak cytotoxicity against K-562 cells. ...[more]

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