The Hard Way towards an Antibody-Based HIV-1 Env Vaccine: Lessons from Other Viruses.

ABSTRACT: Although effective antibody-based vaccines have been developed against multiple viruses, such approaches have so far failed for the human immunodeficiency virus type 1 (HIV-1). Despite the success of anti-retroviral therapy (ART) that has turned HIV-1 infection into a chronic disease and has reduced the number of new infections worldwide, a vaccine against HIV-1 is still urgently needed. We discuss here the major reasons for the failure of "classical" vaccine approaches, which are mostly due to the biological properties of the virus itself. HIV-1 has developed multiple mechanisms of immune escape, which also account for vaccine failure. So far, no vaccine candidate has been able to induce broadly neutralizing antibodies (bnAbs) against primary patient viruses from different clades. However

SUBMITTER: Ringel O 

PROVIDER: S-EPMC5923491 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature