Non-Canonical Activation of the Epidermal Growth Factor Receptor by Carbon Nanoparticles.

ABSTRACT: The epidermal growth factor receptor (EGFR) is an abundant membrane protein, which is essential for regulating many cellular processes including cell proliferation. In our earlier studies, we observed an activation of the EGFR and subsequent signaling events after the exposure of epithelial cells to carbon nanoparticles. In the current study, we describe molecular mechanisms that allow for discriminating carbon nanoparticle-specific from ligand-dependent receptor activation. Caveolin-1 is a key player that co-localizes with the EGFR upon receptor activation by carbon nanoparticles. This specific process mediated by nanoparticle-induced reactive oxygen species and the accumulation of ceramides in the plasma membrane is not triggered when cells are exposed to non-nano carbon particles or the

SUBMITTER: Stockmann D 

PROVIDER: S-EPMC5923597 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature