Platelet activation and aggregation after aneurysmal subarachnoid hemorrhage.

ABSTRACT:

Background

Endovascular techniques have proven beneficial in the treatment of aneurysmal subarachnoid hemorrhage (aSAH), but with high risk of arterial clotting, emboli and dissection. Platelet activation and alterations in hemostasis may contribute to these complications. We investigated platelet activation and aggregation pathways in aSAH patients who underwent endovascular treatment.

Methods

Two blood samples were taken, in the early days after bleeding and during the period at risk of vasospasm. We studied platelet activation through the expression of GpIIbIIIa and P-selectin as well as aggregation rate in the presence of agonists. Platelets from aSAH patients were compared with those from orthopedic postoperative patients (POSTOP).

Results

Platelets in aSAH were

SUBMITTER: Perez P 

PROVIDER: S-EPMC5924502 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature