The Dynamic Landscape of Open Chromatin during Human Cortical Neurogenesis.

ABSTRACT: Non-coding regions comprise most of the human genome and harbor a significant fraction of risk alleles for neuropsychiatric diseases, yet their functions remain poorly defined. We created a high-resolution map of non-coding elements involved in human cortical neurogenesis by contrasting chromatin accessibility and gene expression in the germinal zone and cortical plate of the developing cerebral cortex. We link distal regulatory elements (DREs) to their cognate gene(s) together with chromatin interaction data and show that target genes of human-gained enhancers (HGEs) regulate cortical neurogenesis and are enriched in outer radial glia, a cell type linked to human cortical evolution. We experimentally validate the regulatory effects of predicted enhancers for FGFR2 and EOMES. We observe th

SUBMITTER: de la Torre-Ubieta L 

PROVIDER: S-EPMC5924568 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature