Stress Signaling JNK2 Crosstalk With CaMKII Underlies Enhanced Atrial Arrhythmogenesis.

ABSTRACT:

Rationale

Atrial fibrillation (AF) is the most common arrhythmia, and advanced age is an inevitable and predominant AF risk factor. However, the mechanisms that couple aging and AF propensity remain unclear, making targeted therapeutic interventions unattainable.

Objective

To explore the functional role of an important stress response JNK (c-Jun N-terminal kinase) in sarcoplasmic reticulum Ca²⁺ handling and consequently Ca²⁺-mediated atrial arrhythmias.

Methods and results

We used a series of cutting-edge electrophysiological and molecular techniques, exploited the power of transgenic mouse models to detail the molecular mechanism, and verified its clinical applicability in parallel studies on donor human hearts. We discovered that significantly

SUBMITTER: Yan J 

PROVIDER: S-EPMC5924593 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature