Immunologic and gene expression profiles of spontaneous canine oligodendrogliomas.

ABSTRACT: Malignant glioma (MG), the most common primary brain tumor in adults, is extremely aggressive and uniformly fatal. Several treatment strategies have shown significant preclinical promise in murine models of glioma; however, none have produced meaningful clinical responses in human patients. We hypothesize that introduction of an additional preclinical animal model better approximating the complexity of human MG, particularly in interactions with host immune responses, will bridge the existing gap between these two stages of testing. Here, we characterize the immunologic landscape and gene expression profiles of spontaneous canine glioma and evaluate its potential for serving as such a translational model. RNA in situ hybridization, flowcytometry, and RNA sequencing were used to evaluate im

SUBMITTER: Filley A 

PROVIDER: S-EPMC5924594 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature