Multimodal neuroimaging and behavioral assessment of α-synuclein polymorphism rs356219 in older adults.

ABSTRACT: The single-nucleotide polymorphism rs356219 in the α-synuclein (SNCA) gene has been shown to significantly contribute to an earlier age at onset of Parkinson's disease (PD), and regulates SNCA expression in PD brain regions, blood, and plasma. Here, we used multimodal magnetic resonance imaging (MRI) to study healthy adults with and without the rs356219 risk genotype. Motor and cognitive tests were administered, and all participants underwent functional and structural MRI. Imaging analyses included (1) task-based functional MRI; (2) task-based functional connectivity; (3) free-water diffusion MRI of the substantia nigra; (4) voxel-based morphometry; and (5) surface-based morphometry. There were no differences between the 2 groups in motor and cognitive performance, or brain structure. Howe

SUBMITTER: Burciu RG 

PROVIDER: S-EPMC5924640 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature