Probabilistic tractography-based thalamic parcellation in healthy newborns and newborns with congenital heart disease.

ABSTRACT:

Background

Given the central role of the thalamus in motor, sensory, and cognitive development, methods to study emerging thalamocortical connectivity in early infancy are of great interest.

Purpose

To determine the feasibility of performing probabilistic tractography-based thalamic parcellation (PTbTP) in typically developing (TD) neonates and to compare the results with a pilot sample of neonates with congenital heart disease (CHD).

Study type

Institutional Review Board (IRB)-approved cross-sectional study.

Model

We prospectively recruited 20 TD neonates and five CHD neonates (imaged preoperatively).

Field strength/sequence

MRI was performed at 3.0T including diffusion-weighted imaging (DWI) and 3D magnetization prepared rapid gradient-echo (MPRAGE).

SUBMITTER: Jaimes C 

PROVIDER: S-EPMC5924655 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature