Impaired Production and Diurnal Regulation of Vascular RvD_{n-3 DPA} Increase Systemic Inflammation and Cardiovascular Disease.

ABSTRACT:

Rationale

Diurnal mechanisms are central to regulating host responses. Recent studies uncovered a novel family of mediators termed as specialized proresolving mediators that terminate inflammation without interfering with the immune response.

Objective

Herein, we investigated the diurnal regulation of specialized proresolving mediators in humans and their role in controlling peripheral blood leukocyte and platelet activation.

Methods and results

Using lipid mediator profiling and healthy volunteers, we found that plasma concentrations of n-3 docosapentaenoic acid-derived D-series resolvins (RvD_{n-3 DPA}) were regulated in a diurnal manner. The production and regulation of these mediators was markedly altered in patients at risk of myocardial infarct. These ch

SUBMITTER: Colas RA 

PROVIDER: S-EPMC5924694 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature