Overview of Virus Metagenomic Classification Methods and Their Biological Applications.

ABSTRACT: Metagenomics poses opportunities for clinical and public health virology applications by offering a way to assess complete taxonomic composition of a clinical sample in an unbiased way. However, the techniques required are complicated and analysis standards have yet to develop. This, together with the wealth of different tools and workflows that have been proposed, poses a barrier for new users. We evaluated 49 published computational classification workflows for virus metagenomics in a literature review. To this end, we described the methods of existing workflows by breaking them up into five general steps and assessed their ease-of-use and validation experiments. Performance scores of previous benchmarks were summarized and correlations between methods and performance were investigated.

SUBMITTER: Nooij S 

PROVIDER: S-EPMC5924777 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature