Ontology highlight
ABSTRACT:
SUBMITTER: Timaner M
PROVIDER: S-EPMC5924870 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Timaner Michael M Letko-Khait Nitzan N Kotsofruk Ruslana R Benguigui Madeleine M Beyar-Katz Ofrat O Rachman-Tzemah Chen C Raviv Ziv Z Bronshtein Tomer T Machluf Marcelle M Shaked Yuval Y
Cancer research 20180104 5
Stromal cells residing in the tumor microenvironment contribute to the development of therapy resistance. Here we show that chemotherapy-educated mesenchymal stem cells (MSC) promote therapy resistance via cross-talk with tumor-initiating cells (TIC), a resistant tumor cell subset that initiates tumorigenesis and metastasis. In response to gemcitabine chemotherapy, MSCs colonized pancreatic adenocarcinomas in large numbers and resided in close proximity to TICs. Furthermore, gemcitabine-educated ...[more]