Widespread changes in transcriptome profile of human mesenchymal stem cells induced by two-dimensional nanosilicates.

ABSTRACT: Two-dimensional nanomaterials, an ultrathin class of materials such as graphene, nanoclays, transition metal dichalcogenides (TMDs), and transition metal oxides (TMOs), have emerged as a new generation of materials due to their unique properties relative to macroscale counterparts. However, little is known about the transcriptome dynamics following exposure to these nanomaterials. Here, we investigate the interactions of 2D nanosilicates, a layered clay, with human mesenchymal stem cells (hMSCs) at the whole-transcriptome level by high-throughput sequencing (RNA-seq). Analysis of cell-nanosilicate interactions by monitoring changes in transcriptome profile uncovered key biophysical and biochemical cellular pathways triggered by nanosilicates. A widespread alteration of genes was observed d

SUBMITTER: Carrow JK 

PROVIDER: S-EPMC5924886 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature