NAA80 is actin's N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility.

ABSTRACT: Actin, one of the most abundant proteins in nature, participates in countless cellular functions ranging from organelle trafficking and pathogen motility to cell migration and regulation of gene transcription. Actin's cellular activities depend on the dynamic transition between its monomeric and filamentous forms, a process exquisitely regulated in cells by a large number of actin-binding and signaling proteins. Additionally, several posttranslational modifications control the cellular functions of actin, including most notably N-terminal (Nt)-acetylation, a prevalent modification throughout the animal kingdom. However, the biological role and mechanism of actin Nt-acetylation are poorly understood, and the identity of actin's N-terminal acetyltransferase (NAT) has remained a mystery. Here

SUBMITTER: Drazic A 

PROVIDER: S-EPMC5924898 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature