New class of transcription factors controls flagellar assembly by recruiting RNA polymerase II in Chlamydomonas.

ABSTRACT: Cells have developed regulatory mechanisms that underlie flagellar assembly and maintenance, including the transcriptional regulation of flagellar genes, an initial step for making flagella. Although transcriptional regulation of flagellar gene expression is required for flagellar assembly in Chlamydomonas, no transcription factor that regulates the transcription of flagellar genes has been identified. We report that X chromosome-associated protein 5 (XAP5) acts as a transcription factor to regulate flagellar assembly in Chlamydomonas While XAP5 proteins are evolutionarily conserved across diverse organisms and play vital roles in diverse biological processes, nothing is known about the biochemical function of any member of this important protein family. Our data show that lo

SUBMITTER: Li L 

PROVIDER: S-EPMC5924902 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature